Screenshots of CABAS

 

The main menu

This is the main module of CABAS where the chromosomal aberration data can be fitted to a linear-quadratic equation. Once this is done the user can type in the number of observed aberrations and the number of scored cells. CABAS will estimate the dose together with th 95% confidence limits. Also, the 95% confidence limits of aberrations are computed.

 

 

PBE - Partial Body Exposure

This imodule is used to calculate the dose in the case of a partial-body exposure. A method which allows such a calculation was developed by Dolphin et al. and it was implemented in CABAS in order to estimate a fraction of the body exposed and the dose to the exposed fraction.

 

 

MCELL - Minimal Number of Cells

A frequent question in biological dosimetry is how many cells must be scored in order to confirm or exclude the absorption of a suspected dose. CABAS calculates the 95% confidence limits of a dose based on the number of cells scored. This tool is useful in cases when it is suspected that a person was exposed to a defined dose of radiation. Based on the calibration curve the expected frequency of aberrations and the confidence limits of dose are calculated. The number of scored cells can be modified to achieve satisfactory values of the confidence limits.

 

GF - G-Function

When a radiation accident victim is exposed to radiation either in a fractionated manner or continuously for a period of time of several hours the calibration curve must be modified so as to simulate the fractionated/ protracted exposure scenario. Such modification relies on calculating a time-dependent factor know as the G-function. The user should enter the time over which the exposure occurred (referred to as t) and the mean life-time of chromosomal breaks (referred to as t0, the default value of which is 2h). CABAS calculates the new coefficients and the new values of the absorbed dose.

The odds ratio

A frequent scenario in biological dosimetry is that of a patient suspected to have received a given, low dose of radiation, while the analysis of dicentrics revealed a frequency equivalent to that of the control value. For cases like this it is possible to calculate the odds ratio (OR) of zero dose vs the suspected dose.  In the OR menu the user is asked to enter the suspected dose and to press the COUNT button. CABAS calculates the expected frequency of dicentrics for the suspected dose, the chances of observing aberrations for zero dose and for the suspected dose and the odds ratio. The probability distribution for the dose corresponding to the observed dicentric frequency is shown as a plot at the bottom of the window.

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